Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Use alternatives if available. Ferrlecit may also be administered undiluted as a slow intravenous injection (at a rate of up to 12.5 mg/min) per dialysis session. Compare formulary status to other drugs in the same class. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Applies only to oral form of both agents. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. Steps on how to print your input & results: 1. This information does not assure that this product is safe, effective, or appropriate for you. Applies only to oral form of both agents. iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Venofer treatment may be repeated if iron deficiency reoccurs. Venofer® (iron sucrose) injection, USP is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. Treatment of anemia due to iron deficiency. Assessing new treatment options. 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Minor/Significance Unknown. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. FERAHEME met the predefined criteria for non-inferiority to Venofer . Minor/Significance Unknown. . 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? Avoid or Use Alternate Drug. Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Applies only to oral form of both agents. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Avoid or Use Alternate Drug. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Most Applies only to oral form of both agents. The dosage of iron sucrose is expressed in mg of elemental iron. Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. Applies only to oral form of both agents. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Fulminant symptoms include confusion, sensation of passing out, paleness. Please confirm that you would like to log out of Medscape. Avoid or Use Alternate Drug. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. VenAccess is a trademark of Vifor (International) Inc. Switzerland. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Monitor Closely (1)lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Corrected Sodium and Effective Osmolality. Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. Many patients with kidney disease cannot get enough iron from food and require injections. Applies only to oral form of both agents. Applies only to oral form of both agents. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . World J Gastroenterol; 16(22): 27202725. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. Use Caution/Monitor. Nutrition. Pediatric Patients (2 Years of Age and Older). 1990 Feb;24(2):162-6. It should be recognized that iron storage may lag behind the appearance of normal blood morphology. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. iron sucrose decreases levels of manganese by inhibition of GI absorption. The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. Venofer has not been studied in patients younger than 2 years old. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Applies only to oral form of both agents. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? Applies only to oral form of both agents. Human studies not conducted. This drug is available at the lowest co-pay. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. [. Mode of Administration: Administer Venofer only intravenously by slow injection or by infusion. iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Venofer is given as an infusion into a vein. Applies only to oral form of both agents. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. Each mL contains 20 mg of elemental iron. It can be expressed in mg per ml. iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Minor/Significance Unknown. Included in the iron dextran package insert. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. Medicinal forms The iron deficit calculator is useful as one of the determinations performed before iron replenishment therapy is initiated. and formulary information changes. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] . Applies only to oral form of both agents. For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. There are four fields that need to be completed: Weight body weight is used to establish iron deficit and is also taken into account when estimating the iron stores. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Anaphylaxis may occur with IV iron and resuscitation facilities should be available.11 It would appear that iron polymaltose may have a higher incidence of severe systemic reactions than iron sucrose and ferric carboxymaltose. Avoid or Use Alternate Drug. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. Your list will be saved and can be edited at any time. *Repeat dose if iron deficiency anemia reoccurs. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. Applies only to oral form of both agents. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Injection site discoloration has been reported following extravasation. Applies only to oral form of both agents. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Prior to and at regular intervals during parenteral iron therapy, evaluate serum iron, hemoglobin, and hematocrit. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Use Caution/Monitor. prescription products. Applies only to oral form of both agents. Monitor Closely (1)deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Reactions have occurred following the first dose or subsequent doses of Venofer. Drug class: Iron products. View the formulary and any restrictions for each plan. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. iron sucrose decreases levels of minocycline by inhibition of GI absorption. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. Use Caution/Monitor. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Interaction only with oral iron administration. Treatment of anemia due to iron deficiency. (See also Notes section. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. David McAuley, Pharm.D. Use Caution/Monitor. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. Parenteral iron dextran therapy. All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. 2015: 763576. Applies only to oral form of both agents. Minor/Significance Unknown. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. If you have private insurance, Venofer or Monoferric may be on the list of covered medications. Deferasirox chelates iron. Avoid or Use Alternate Drug. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. Applies only to oral form of both agents.
Second Chance Leasing Garland, Tx,
Leaving Main Street Summary,
Articles V