20 May 2021. on SARS-CoV-2 antibodies in breast milk following vaccination, told us there is no evidence to support Bridles claims. Updated 21 June 2021. The information is. The new findings could help explain . SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy bioRxiv. A lot of people think of it as a respiratory disease, but its really a vascular disease, says Assistant Research Professor Uri Manor, who is co-senior author of the study. This "teaches" the body's immune system to fight the virus that has that specific spike . The Pfizer and Moderna vaccines work by introducing mRNA (messenger RNA) into your muscle cells. Accessed 29 June 2021. (The chief hope, apparently, is to limit hospitalizations/death not necessarily case case counts, many of which may presumably become asymptomatic following vaccination.) The spike protein encoded by the mRNA vaccines (Moderna and Pfizer/BioNTech) and the J&J vaccine instruct the cells in our arm (where the injection is given) to produce spike protein that is tethered to the surface of the cell. PolitiFact, "No proof for researcher claim that COVID-19 vaccines' spike protein is a 'toxin,'" June 7, 2021. The spike also activates CD4 and CD8 T cells from anywhere beyond 70% of COVID-19 patients . It must first be understood by all. Even if the spike protein was absorbed into the blood stream, it has no mechanism of action to cause any issues such as bleeding disorders., According to the CDCs website there is limited data available on the safety and the effects of vaccination in lactating people or breastfed babies because the clinical trials didnt include people who were breastfeeding. Bridle, Bryam. The same harmless mutation, called 2P, as in two proline molecules, is used in the SARS-CoV-2 vaccines. The pathogenecity of the S-protein was not yet realized until long after the so-called vaccine was created and released. According to the Centers for Disease Control and Prevention, the most intensive safety monitoring in U.S. history has found that most of the reported side effects after COVID-19 vaccination are minor, such as pain at the injection site or fever. Low, Jia Ming, et al. It yielded the first COVID-19 vaccines, Fact check: COVID-19 vaccines dont produce dangerous toxins, Why Parents, Teens, and Children Should Question the COVID-19 Vaccine. FactCheck.org reached out to Bridle for comment. The team then replicated this process in the lab, exposing healthy endothelial cells (which line arteries) to the spike protein. influenza and now COVID-19, will collaborate with The Rajasree Kalagiri Bound to phosphohistidine. Before it is destroyed it causes micro clots if the spike producing cell is part of the endothelial cell wall. If successful, this approach could be How long mRNA lasts in the body. . Circulation Research. For instance, behold Alex Berenson, the " pandemic's wrongest man ", crowing about the study: As smoking guns go, this study is high-caliber. that happened with all Covid (and other) vaccines in use today? while a professor at the Salk Institute, Holley shared the Nobel Prize for his work on how these . This suggests a successful immune response doesn't concentrate on the RBD. The CDC and FDA vaccine safety monitoring systems, which were expanded for the COVID-19 vaccines and also include a new smartphone-based reporting tool called. Reference: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2 by Yuyang Lei, Jiao Zhang, Cara R. Schiavon, Ming He, Lili Chen, Hui Shen, Yichi Zhang, Qian Yin, Yoshitake Cho, Leonardo Andrade, Gerald S. Shadel, Mark Hepokoski, Ting Lei, Hongliang Wang, Jin Zhang, Jason X.-J. structures of the SARS-CoV-2 virus, together with proprietary Mar 2020. World Health Organization. Assistant Professor Dmitry Lyumkis discusses what he loves about data and the scientific process, and which places inspire him outside the lab. Who committed such evil ? Retweet. the immune response to these spike proteins. Having said that, a more complete answer would depend on the age and health status of the vaccinated individual. COVID vaccines and breastfeeding: what the data say, American College of Obstetricians and Gynecologists. The underlying mechanism involves S protein downregulation of AMPK and upregulation of MDM2, causing ACE2 destabilization. Email sent to FactCheck.org. Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients. The majority of people wouldnt even know they had covid. Most, if not all of you people are idiots you just want to be heard and want to rant pseudoscience, and no where remotely close. Another monitoring system is the CDCs Vaccine Safety Datalink, which uses electronic health data from nine health care organizations in the U.S. to identify adverse events related to vaccination in near real time. There is no evidence to indicate that the spike proteins generated by human cells following vaccination are a toxin or that they circulate in the body and damage tissues, contrary to what a Canadian virus immunologist recently claimed. . Canadian Covid Care Alliance. Shyy, 31 March 2021, Circulation Research.DOI: 10.1161/CIRCRESAHA.121.318902. BUT: Then the immune system will destroy that cell (also some brain cells which will not regenerate). inflammatory proteins called cytokines, colloquially known as The vaccine allows the body to recognize spike proteins so it can learn to fight them, without the risk of a virus that can replicate spike proteins to the point of killing a person. Aging is a complex puzzle, but by applying a collaborative, multidisciplinary approach, Salk scientists are putting its many pieces together. This is because the normal spike protein must change its shape in order to achieve fusion with the ACE2 receptor. Instead, each carries molecular instructions, called messenger RNA (mRNA), that tell our bodies how to fight off the virus. chances of spreading. If a burgler, theoretically, is born inside your house and cannot get out alive and is killed by the residents, there is no damage and no damage in the future at other houses. NSP1 halts host protein production. 5 Immune Response Some immune cells latch onto the spikes and produce antibodiesY-shaped molecules that will recognize spike proteins and block them from getting inside other cells. This article is a reprint of what I assume is the original source here: https://www.salk.edu/news-release/the-novel-coronavirus-spike-protein-plays-additional-key-role-in-illness/. In fact, recent studies show breastfeeding after vaccinations may provide babies with protection. Accessed 29 June 2021. 14. I am familiar only in part with some of the details you explain.I wonder in the optimistic scenario, which I want to believe, then what triggered the not to many but enough to ask cases of thrombocytopenia? William, its been known since early in the pandemic that maybe 50% of people are not susceptible (that is, who dont have visible symptoms). Vaccination is a calculated risk and with tried and true vaccines the risks are very rare, but no vaccine is safe in that deaths and injuries occur due to allergies, negligence and medical incompetence. New research: Besides initiating infection, coronavirus spike protein has key role in illness The paper also finds that Covid-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system (comprising the blood vessels) on a cellular level. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827936/#:~:text=SARS%2DCoV%2D2%20uses%20its%20viral%20membrane%20fusion%20protein%2C,(ARDS)%20%5B5%5D. Only small fragments of the ubiquoitim proteosome protein degradation process of the induced spike protein are presented on the surface of the cell by the MHC 1 ANTIGEN presentation system. Show replies. My first instinct would be to blame any Fall/Winter COVID-19 spike on the fact that vaccine-induced immunity is temporary with some estimates as little as 6-9 months (the apparent hope, however, is that we can go 12 months between boosters). vascular wall thickening the hallmark of Pulmonary artery hypertension. via rigorous testing in clinical trials prior to authorization or approval, followed by continued safety monitoring once the vaccine is rolled out to the public to detect potential rare side effects. It involves production of antibodies capable of covering areas across the entire spike. While previously working on a vaccine for MERS, a disease caused by another coronavirus, McLellan and others, that by adding two proline molecules to the spike protein, they could lock it into its pre-fusion state, triggering a more effective immune response and preventing cell entry. So by vaccinating people we are inadvertently inoculating them with a toxin.. Prompting an Immune Response Health Canada authorizes use of the Pfizer-BioNTech COVID-19 vaccine in children 12 to 15 years of age. Press release, Government of Canada, Health Canada. So far, your assumption is true. The mRNA vaccines builds the protein within the safe environment of the host cell structure from the inside outspikes are not created outside this environment. Emails are serviced by Constant Contact. Given this, what other explanation can there be apart from a lower rate of vaccine effectiveness than we have been led to believe? The mRNA vaccination process hijacks the cell to encode these proteins so were not talking a limited number taken up by the vaccine itself after which no more are produced by the body. The, unpublished study found antibodies in the breast milk from all of the workers andminimal amounts of vaccine mRNA., document, instead saying that detection of the mRNA was downplayed., is designed to detect potential problems thats why its there but it does not show whether the vaccines. What leads you to believe that the spike protein will remain in the cell vs. expressed into the surrounding tissue by which not only antibody response will be built up (a good thing) but also attack by NK cells (another aspect of the immune system) and thus pro-thrombotic, pro-inflammatory aftereffects? Here is a quote the prevalence of the South African strain among vaccinated individuals who were infected despite their inoculation was eight times higher than its prevalence in the unvaccinated infected population. They are produced INSIDE cells, right where they want to be. Jaramillo, Catalina. The Salk Institute proves this assumption to be dangerously inaccurate." (source) Can this Newly Manufactured Synthetic Spike Protein Be Transmitted to the Unvaccinated? Manor labs and Ogata's study confirm. The commonality between them is that they all have vascular underpinnings.. That if one drink from it ! Researchers detected levels of SARS-CoV-2 protein as early as one day after the first injection in 11 of the 13 participants. Does that mean people who are vaccinated face the same health risks as COVID-19 itself? University of Guelph. An open space or just an open window could reduce the virus transmission. shows that SARS-CoV-2's "distinctive 'spike' protein . In fact, the antibodies that the mother has can go through the breast milk to the baby and may only serve maybe to protect the baby a little bit. COVID-19 Vaccines While Pregnant or Breastfeeding. And so theres no risk of transmission through the breast milk. 17 June 2021. Your support will accelerate the pace of breakthroughs in understanding disease and pave the way to new drug therapies. Ghazvini, Keanna. COVID-19 vaccines do not contain a live virus, so there isn't a biological path for a vaccinated person to "shed" the SARS-CoV-2 spike protein to those around them. helps the virus in promoting the production of its own viral He is also the host and producer of the popular weekly science podcast, The Skeptics' Guide to the Universe, and the author of the NeuroLogicaBlog, a daily blog that covers news and issues in neuroscience, but also general science . This is an a synthetic form of Human Vasoactive Intestinal Polypeptide (VIP). There is no screening or vetting of the report and no attempt to determine if the vaccine was responsible for the problem. The document is about the pharmacokinetics overview seen from lab studies and we can confirm its not about spike proteins from the vaccine resulting in dangerous toxins that linger in the body, Ghazvini said. Indeed, there are those who have looked at the vaccine clinical trial data and made the observation that the rate of COVID-19 cases among the control group was too small relative to the reduction of cases in the vaccinated group to extrapolate a high rate of effectiveness for vaccines. Yuan, Atul Malhotra, Jin Zhang of the University of California San Diego; Lili Chen, Qian Yin, Ting Lei, Hongliang Wang and Shengpeng Wang of Xian Jiatong University Health Science Center in Xian, China. overcome intractable clinical challenges, not just of SARS CoV- Other parts of the immune system such as killer Tcells will destroy the spike protein infected cell with its exterior attached spike protein. There is no risk at all because all the vaccines that are being used presently, none of them have the live virus in it. with the Sanford Burnham Prebys Medical Discovery Institute Now, a major new study shows that they also play a key role in the disease itself. Covid makes most people not ill at all or a little ill as well.No one knows that. He posted a good link. Weiss, Susan. Honestly i think you have a bigger problem to worry about then the vaccine Bailey. https://youtu.be/t9VObXY8szchttps://clinicaltrials.gov/ct2/show/NCT04311697, Aviptadil is now in internatial research project with Remdesivir, which could help in start of the sickness.https://www.nih.gov/news-events/news-releases/clinical-trial-therapeutics-severely-ill-hospitalized-covid-19-patients-begins. Pamela Maher Seeking treatments for Alzheimers disease. Watch this https://youtu.be/9EfToFXwx98?t=479, Wrong. Are their other unknown factors that give them natural immunity? Safety of COVID-19 Vaccines. CDC.gov. BNT162b2 vaccination induces SARS-CoV-2 specific antibody secretion into human milk with minimal transfer of vaccine mRNA, Viral Posts Misuse VAERS Data to Make False Claims About COVID-19 Vaccines. The research was supported by the National Institutes of Health, the National Natural Science Foundation of China, the Shaanxi Natural Science Fund, the National Key Research and Development Program, the First Affiliated Hospital of Xian Jiaotong University; and Xian Jiaotong University. And it is located upon a plateau. See: https://www.regulations.gov/document/FDA-2020-N-1898-0246. He will There is no evidence that the spike protein in vaccines is toxic or that it lingers at any toxic level in the body after vaccination, an FDA spokesperson told us in an email. Thats because the SARS-CoV-2 spike protein is a shape-shifter. Taken together, it looks as if Operation Warp Speed delivered a questionable vaccine but to recoup their losses Big Pharma still needs to put the jab into peoples arms even though much more is unknown than known! However, the displayed parts also cause the innate immune system to attack and destroy the cell wall. Alan Saghatelian and Joseph Noel are exploiting the atomic spike protein, SARS-CoV-2 Angiotensin-Converting Enzyme 2 Grant support R01 HL106579/HL/NHLBI NIH HHS/United States . Professors Clodagh OShea, But, he said, there is one key difference, in that the spikes encoded by the vaccines contain 2 amino acid changes that help stabilize the spike in its initial conformation and help prevent the spike from undergoing a conformational change that is required to facilitate membrane fusion.. University of Guelph. combine CRISPR with an imaging technology, so that it will only Structural biologist at the University of Texas at Austin. Of course, none of this even begins to account for how vaccines will alter our immune response, for better or for worse, to COVID-19 variants. Its internationally renowned and award-winning scientists explore the very foundations of life, seeking new understandings in neuroscience, genetics, immunology, plant biology and more. Your mis-information is just as bad as some antivaxxers. If you have access to any vaccine, please take it, they are all good to protect you and your loved ones. Continue with Recommended Cookies, Representative images of vascular endothelial control cells (left) and cells treated with the SARS-CoV-2 Spike protein (right) show that the spike protein causes increased mitochondrial fragmentation in vascular cells. https://youtu.be/9EfToFXwx98?t=479. will target i) SARS-CoV-2 prevention by creating synthetic Pharmacokinetics is the study of how a drug moves through the body, including how quickly drugs are absorbed, metabolized, and excreted.
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